QuadraSil is derived from high quality, spherical organo-functionalised silicas and neatly complements Reaxa's QuadraPure range of polymer based scavenging resins.
The initial QuadraSil range includes primary amine functionality (QuadraSil AP); mercapto functionality (QuadraSil MP); thiourea functionality (QuadraSil MTU) and triamine functionality (QuadraSil TA).
QuadraSil will rapidly remove metal contaminants even in the presence of competing, complexing phosphine ligands and co-ordinating products.
Application benefits of QuadraSil include fast kinetics, with metal removal often complete within ten minutes at room temperature, and high temperature stability.
Additionally, the zero swell characteristics in organic solvents and spherical particle size enhance application in packed beds or cartridges.
Although primarily targeted at applications within early phase development campaigns and R&D, the favourable economics of this technology should encourage large scale manufacturing applications.
QuadraSil demonstrates high loading in comparison to other commercially available silicas and can be used in both aqueous and organic solvents, without pre-wetting.
"Increasingly stringent pharma legislation is challenging conventional approaches to API and key intermediate purification," said Reaxa's chief technology officer David Pears.
"QuadraSil represents a more efficient and faster solution that avoids the waste of highly valuable product."
By expanding the range of products, the latest QuadraSil scavengers extend clean-up performance to solve a wider range of metal contamination problems in pharma processing.