Fred Hutch to use Origin Sciences' OriCol in Ph I HIV study

By Melissa Fassbender

- Last updated on GMT

Fred Hutch to use Origin Sciences' OriCol in Ph I HIV study
Fred Hutchinson Cancer Research Center will use Origin Sciences’ novel mucosal sampling device, OriCol, for sample collection as part of a Phase I HIV study.

Fred Hutch selected OriCol for this HIV prevention study after experiments testing and optimizing the device in control subjects​,” Paul Weinberger, Origin Sciences' CEO told Outsourcing-Pharma.com.

The main criteria for OriCol selection was the collection time is less when compared to our usual secretion collection methods while still obtaining a similar sample​.”

Weinberger explained the device allows clinicians to take secretion samples in less time, adding that this “typically means increased participant comfort​.”

The sampling device

UK-based Origin Sciences developed The OriCol™ Sampling Device​ to enable clinicians to collect a unique mucosal sample for detection and diagnosis of gastrointestinal diseases.

According to the company, samples can be used in a range of downstream analyses including investigation of DNA, proteins, antibodies and the microbiome.

The Phase I HIV study

As part of the study, mucosal samples will be collected from the rectum of the study subjects. The samples will then be measured for Immunoglobulin (IgG) levels to monitor patients’ responses to experimental treatment.

The Phase I study will test two experimental antibodies: VCR01 and VCR01LS, which Fred Hutch said can recognize and block many HIV forms. It has also shown an ability to block HIV infection in previous studies.

According to the company, the study’s aim is to evaluate the safety, pharmacokinetics, and antiviral activity of VRC01 and VRC01LS in the serum and mucosa of healthy, HIV-uninfected adults.

(Feature image: iStock/Weedezign)

Related news

Related products

show more

Using Define-XML to build more efficient studies

Using Define-XML to build more efficient studies

Content provided by Formedix | 14-Nov-2023 | White Paper

It is commonly thought that Define-XML is simply a dataset descriptor: a way to document what datasets look like, including the names and labels of datasets...

Overcoming rapid growth challenges with process liquid preparation

Overcoming rapid growth challenges with process liquid preparation

Content provided by Thermo Fisher Scientific - Process Liquid Preparation Services | 01-Nov-2023 | Case Study

A growing contract development manufacturing organization (CDMO) was challenged with the need to quickly expand their process liquid and buffer preparation...

Why should you use clinical trial technology?

Why should you use clinical trial technology?

Content provided by Formedix | 01-Nov-2023 | White Paper

New, innovative clinical trial technology is helping to revolutionize the research landscape. COVID-19 demonstrated that clinical trials can be run much...

Related suppliers

Follow us

Products

View more

Webinars