AstraZeneca doubles down on US manufacturing with $3.5 billion investment

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AstraZeneca has become the latest big pharma company to devote new cash to its US manufacturing muscle this year as it unveils a $3.5 billion infusion into US sites.

With around $2 billion of the investment dedicated to creating more than a thousand U.S. jobs, AstraZeneca is looking to expand R&D and manufacturing facilities in states including Massachusetts, Maryland, and Texas dedicated to specialty manufacturing, biologics and cell therapies.

The £158.7 billion ($200.8 billion) market-cap player is among the top ten biggest pharmaceutical companies in the world, with landmark products including the small molecule diabetes drug dapagliflozin (Farxiga) and cancer medications osimertinib (Tagrisso) and acalabrutinib (Calquence).

AstraZeneca’s latest investment in the U.S. comes as part of the company’s mission to expand its research and manufacturing capabilities by the end of 2026 and to hit $80 billion in total revenue by 2030.

“Our multibillion dollar investment reflects the attractiveness of the business environment together with the quality of talent and innovation capabilities here in the United States,” said AstraZeneca CEO Pascal Soriot in a public statement. “By expanding our R&D and manufacturing footprint, we aim to enhance the development of cutting-edge therapies and support the United States leadership in healthcare innovation.”

AstraZeneca’s move echoes those of other pharmaceutical firms increasing their foothold in the lucrative U.S. market, which makes up 44% of AstraZeneca’s revenue. For example, GSK recently sank $800 million into a site in Pennsylvania to double its capacity, while Novo Nordisk earmarked $4.1 billion for a new manufacturing facility in North Carolina earlier this year.

AstraZeneca unveiled a 19% increase in its total revenue to $39.1 billion over the last nine months in a recent earnings report, which was driven by growth in product sales and income from partnered candidates. The firm now sees high teens percentage growth in its total revenue for the whole year 2024.

Some of the biggest earners for AstraZeneca this year include Farxiga with $5.7 billion, Tagrisso with $4.8 billion and durvalumab (Imfinzi) with $3.4 billion.

However, it is not all smooth sailing for the big pharma company, with some of its current and former employees, including EVP International and AstraZeneca China President Leon Wang, under investigation in China with allegations of medical insurance fraud, illegal drug importation and personal information breaches.

“We take the matters in China very seriously. If requested we will fully cooperate with the authorities,” stated Soriot in the earnings report.