Archives for January 5, 2005

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New target identified in osteoarthritis

Using naturally occurring mutant mice with a defective collagen gene, scientists at Harvard have identified a signalling molecule involved in osteoarthritis, one of the most common causes of disability among the elderly.

Crucell strengthens PER.C6 DSM deal

By  Wai Lang Chu

Crucell and DSM have announced the expansion of its original agreement, building on existing work achieved in the PER.C6 Protein and Monoclonal Antibody Licensing Business.

Tufts publishes Outlook document for 2005

Drug companies can significantly increase the flow of new prescription drugs, while maintaining patient safety, if they adopt more innovative R&D strategies aimed at improving clinical success rates and lowering clinical study costs, according to the...

Green fluorescent protein reagent improved

Researchers in the US have developed a fluorescent tag for proteins - based on a fragment of green fluorescent protein (GFP) - that can penetrate cells and so be used to detect proteins in living cells and cell lysates.

NSAIDs linked to small intestine damage

Non-steroidal anti-inflammatory drugs (NSAIDs) are more likely to cause gastrointestinal side effects than has been thought, according to the results of a small study, reports Wai Lang Chu.

Drug delivery firm aims to solve NSAID problems

The withdrawal of Merck & Co's COX-2 inhibitor Vioxx (rofecoxib) because of cardiovascular safety issues - and concerns about the safety of other drugs in the class - have left doctors with some difficult prescribing decisions for their arthritis...

SAFC starts work on high potency expansion

In keeping with the current trend among contract manufacturing organisations to tap into niche markets, SAFC has started construction of a new facility aimed at meeting the demand for manufacturing of highly potent active pharmaceutical ingredients...

Process development service tackles QC issue in biopharma

The rapid growth in the development and commercialisation of new biological entities (NBEs) has been one of the major trends in the pharmaceutical sector over the last few years, but their production can be said to be more of an art than a science.

Packaging machinery market to top $31bn in 2008

World demand for packaging machinery is projected to rise over 4 per cent per year (including price increases) through 2008 to over $31 billion, with developing nations expected to register the strongest market gains, according to a recently published...