Separation tech for oligo research
that could improve the yield, purity and length of oligonucleotide
sequences.
Under the terms of the collaboration, Berry & Associates has launched a line of fluorous-adapted oligonucleotide synthesis products based on a proprietary fluorous synthesis and separation technology developed by Fluorous Technologies.
Oligonucleotides, which are small synthetic fragments of the nucleic acids DNA and RNA, are widely used in biomedical research, as therapeutics, and as diagnostic probes for the detection of genetic mutations. Laboratory synthesis of oligonucleotides has been essential to the molecular biology revolution; however, purification challenges have historically limited the yield, purity and the maximum length of oligonucleotides that can be obtained.
Fluorous chemistry is a widely adaptable, fast, and selective separation technology. New to science in the past decade, fluorous affinity tags act as molecular handles for purification without affecting any other aspect of the chemistry. After placing a fluorous tag on an oligonucleotide by means of traditional solid-phase techniques, the tagged material can be easily separated from impurities. The tag is then removed, leaving the pure product.
With the new collaboration, Berry & Associates has extended Fluorous Technologies' foundation technology to oligonucleotide synthesis.
