The pressures placed on pharmaceutical and biotechnology firms are
causing companies to outsource their drug discovery processes as
contract research organisations (CROs) expand to offer services
such as finance/accounting, logistics...
Cellectricon has launched a new chip for safety pharmacology and
hERG studies, which aims to provide a solution to the current need
for increased throughput and data quality in ion channel drug
discovery that has plagued drug researchers.
Gedeon Richter and Forest Laboratories have expanded their
collaboration by forming two additional agreements involving two
novel mechanisms targeted for the treatment of CNS conditions,
building upon the existing collaboration announced...
SemBioSys Genetics has demonstrated bio-equivalence of a
plant-produced insulin, which if realised, could become a viable
alternative to meet the demand for insulin as the incidence of
diabetes increases worldwide.
A US district court has denied a motion by Bio-Rad Laboratories to
enforce an alleged settlement agreement with Applied Biosystems
meaning the life science research product provider cannot continue
selling its thermal cycler products.
Researchers have identified two proteins involved in the process
that controls plant growth, which may help explain why human cells
reject chemotherapy drugs and could form a basis for new oncology
drugs.
Increasing knowledge about how to manage the risks of gene therapy
is set to usher in a new era in disease therapies, with the
prospect of developing treatments in treating rare, inherited, or
life-threatening diseases very real.
Researchers have shown how protein synthesis is targeted to certain
regions of a cell, a process crucial for the cellular motility,
which could form a basis for producing a drug that could force
tumour cells to express this protein,...
The need to analyse voluminous data is set to create a wealth of
opportunities for bioinformatics in which systems integration
capabilities are predicted to boost uptake of bioinformatics and
clinical informatics in drug discovery...
Pfizer and Incyte have entered a collaborative research and license
agreement for the development and commercialisation of CCR2
antagonists - an emerging class of drug that aims to serve an unmet
need in the treatment of rheumatoid...
Scientists have noted that stimulating brain cell receptors for
certain hormone-like chemicals in brain cells can protect them from
a compound linked to brain cell death and Alzheimer's disease (AD).
Researchers have combined nanotechnology with biochemistry to
create synthetic membranes that, for the first time, enable direct
control of signalling activity in living T cells from the immune
system, which could lead to better development...
A new class of chiral stationary phases (CSPs) for analytical and
preparative-scale high performance liquid chromatography (HPLC),
has been launched by ZirChrom Separations, which further enhances
HPLC as a method of choice for chiral...
Millipore Corporation today announced two tangential flow
filtration (TFF) products that allow researchers to efficiently
purify large volumes of protein-containing solutions that
accelerate drug screening and improve sample preparation.
Vasogen announced preclinical data this week, demonstrating the
ability of its lead drug candidate to modulate key signalling
pathways associated with inflammation, demonstrating therapeutic
potential in a range of neurological disorders.
Schering-Plough has entered into an agreement with Oncomethylome
Sciences (OMS), which allows the pharma giants to use OMS
Pharmacogenomic technology to study MGMT methylation status in
brain cancer patients.
Drug development services company, Aptuit, has finalised a deal to
acquire InfoPro Solutions, which adds informatics services to
Aptuit's portfolio, as well as the Clinicopia Suite, which enables
customer access to drug development...
Kreatech Biotechnology launches its latest small RNA kit that
targets microRNA and siRNA arrays that directly labels any and all
sizes of naturally occurring nucleic acids without the need of
enzymes.
According to a recent report, analytic separation technology will
continue to evolve as limitations are addressed and standards grow
even more rigorous, as market drivers such as quality control,
instrument design, and software in...
A group of researchers have found that FLT-1 - a molecule
implicated in blood vessel growth - is necessary for the escape of
the leukaemia cells from the bone marrow (BM), suggesting that
blocking of this molecule pharmaceutically...
TorreyPines Therapeutics has initiated a phase I clinical trial for
its first-in-class compound, which claims to offer a non-opioid,
non-vascular approach to the management of severe pain.
Pain Therapeutics and King Pharmaceuticals have entered into an
alliance to develop and commercialise Remoxy in an alliance worth
at least $400 million (€342 million). The deal positions the
abuse-resistant opioid painkiller as a...
Sophion Bioscience and Physio-Tech have signed an agreement in
which Physio-Tech will become the exclusive distributor of Qpatch
16 systems in Japan, signifying its introduction into the Asian
market.
A small molecule drug, which has been developed to treat solid
tumour and haematological cancer, has entered an Investigational
New Drug (IND) application that represents the emergence of aurora
kinase inhibitors as a viable cancer...
German biotech company Evotec OAI boosted its third quarter
revenues by 18 per cent to €19 million, despite the difficult
operating environment for companies supplying drug discovery
technologies, continuing its recovery from a weak...
Varian has announced it is to acquire Polymer Laboratories for $42
million (€35.7 million)in a transaction that adds consumables and
instrumentation for Gel Permeation Chromatography (GPC) analysis to
its product portfolio.
Nikon Instruments have launched a series of software and
application enhancements for spectral imaging applications, which
are used extensively in drug discovery and cell biology.
A Phase I clinical trial, which is investigating the
pharmacological activities of a compound for the treatment of
Alzheimer's disease, has just been completed with results
indicating improved efficacy and pharmacokinetics over...
Biochip technology has redefined the process of drug discovery with
partnerships central to accelerating adoption levels and expanding
revenues in a market that is reinforced by strong bioinformatics
infrastructure and standardisation...
Contract research specialists Xceleron have announced a new
three-year deal that provides support for GSK's bioanalytical AMS
programme for human metabolite profiling and obtaining mass balance
data.
An affirmation that aims to replace the use of laboratory animals
in testing was agreed in Brussels by key industry sectors
representing the European chemical, pharmaceutical and
biotechnology industries.
A diagnostic test, which monitors anti-HIV drugs in the blood, is
set to enter development to eventually become available across
Europe. The test will be used to identify the correct dosage of
medicine for individual patients.
Beckman Coulter, launch its second offering in its new family of
flow cytometers for drug discovery and basic clinical research. The
new addition aims to expand study parameters of flow cytometry by
incorporating side scatter measurement...
Scientists have admitted that an unexpected genetic phenomenon in
prostate cancer has changed conventional thinking over approaches
in drug treatment of breast, colon and lung malignancies.
Scientists have discovered how good cholesterol (HDLs) provide
human immunity to certain parasites, which may serve as a platform
for the assembly and delivery of two naturally occurring proteins
that combine to create a super-toxic...
According to a new report, more than 400 new medicines are in
development to treat diseases that affect US women, including 62
medicines now in testing to treat breast cancer.
Scientists from the US have discovered that compounds secreted by
frog skin could be used as a successful treatment in the fight
against HIV infection, which if developed further, could form an
effective pharmaceutical treatment.
Simulations Plus has announced the release of a new hERG potassium
channel blocking affinity model that extends the capabilities of
its ADMET Predictor software in the area of cardiac drug toxicity.
The selection of pharma and biotech companies reporting results for
the third quarter of 2005 provided mixed indications as to the
state of the industry. Pipeline product fruition may be returning
among the industries as DrugResearcher.com...
Viscotek
launches its latest entry-level system for laboratories looking to
conduct characterisation of proteins, and other biomolecules,
allowing researchers to make a determination of absolute Molecular
Weight, a traditionally...
According to a new study, the worldwide market for in vitro cancer
diagnosis will reach the $7.4 billion (€6.1 billion) mark by 2009,
as the demand for such tests will continue to increase as new
cancer cases soars toward the 10 million...
US researchers have discovered how cancer cells communicate with
each other that is crucial to the tumour growth and motility of
cancer cells. By inhibiting this process via pharmaceutical
intervention, successful treatment of a range...
Biolex Therapeutics and Kringle Pharma have announced a
collaboration for the production of a novel protein targeting
cancer. The protein is thought to be inefficient to produce with
traditional expression systems.
Researchers have demonstrated the precise movements of an enzyme
during replication that may serve as a precursor to understanding
genetic disease caused by abnormal enzyme activity.
Scientists have described it as an achievement that will
revolutionise medicine as the first genetic "map" of human
diversity was published. The gene map, which details common
differences in the human genome, could lead...
Genetic diagnostics is driving improvements in modern day medical
treatment with the move towards personalised medicine and
prevention-oriented healthcare all opening up market opportunities
for genetic pinpointing techniques.
Agilent Technologies launches its latest microarray solution for
analysing activity at regulatory regions of genomes, enabling
researchers to examine gene regulation in a more efficient and
cost-effective manner.
Medisyn Technologies has entered into agreement with Humanetics
that aims to drive the discovery of natural compounds that can
offer safe, natural therapeutic options in the areas of obesity,
immune system and cognitive function.
The first melatonergic antidepressant to offer a new approach to
the treatment of depression is just over the horizon after new data
demonstrated positive efficacy with marked improvements in sleep
with no effect on daytime vigilance.
Animal rights activists, who engage in acts of violence, could be
prosecuted under new anti-terror legislation proposals outlined by
the Government that aim to crack down on recent attacks on British
Universities with animal research...