Preclinical

The Omentum Project - a frank and honest discussion with two time ovarian cancer survivor, Meg Wilkinson

05-Jul-2024 By Liza Laws

Meg Wilkinson, a resilient cancer survivor, recently sat down with OSP editor Liza Laws to discuss her journey from diagnosis to founding the Omentum Project.

Tyra Biosciences' TYRA-300 shows promise for hypochondroplasia treatment

04-Jul-2024 By Clara Rodriguez Fernandez

Preclinical results show promise for Tyra Bioscience’s lead drug candidate for the treatment for hypochondroplasia, a condition for which there are currently no therapeutic options available.

Exclusive interview: Diane Lacroix talks innovations in clinical data management

04-Jun-2024 By Liza Laws

In celebration of Clinical Trials Day last month, OSP sat down with Diane Lacroix, vice president of clinical data management at eClinical Solutions, to delve into the latest advancements and future directions in clinical trials.

Shionogi and Maze seal worldwide exclusive in bid to cure Pompe disease

10-May-2024 By Liza Laws

In an interesting development in the field of rare disease therapeutics, Shionogi & Co., Ltd., and Maze Therapeutics, Inc. have sealed an exclusive worldwide license agreement for MZE001, a novel therapeutic candidate aimed at tackling Pompe disease.

Significant strides made in Nxera Pharma's oral compound for neurological conditions

09-May-2024 By Liza Laws

Neurocrine Biosciences Inc. has initiated its phase 1 clinical study, marking a significant stride in the evaluation of NBI-1117567, an investigational small molecule, oral compound developed by Nxera Pharma.

Interview: Thermo Fisher Scientific's Sarah Englert on opening the doors to its new innovation hub

18-Apr-2024 By Liza Laws

Yesterday, Thermo Fisher Scientific opened its first Innovation Lab in Center Valley, Pennsylvania., as a space where partners can come together to collaborate, innovate, and ideate on solutions to the biggest clinical supply chain pain points.

Untreated CKD expected to become world's fifth leading cause of death by 2040 - and 90% are unaware they have it

18-Apr-2024 By Liza Laws

On Monday, OSP published a story about AstraZeneca’s latest modeling analysis which highlighted major concerns about the future of chronic kidney disease (CKD) across eight countries.

Nxera Pharma's oral receptor agonist advances in schizophrenia trials with successful preclinical milestone

16-Apr-2024 By Liza Laws

Nxera Pharma Co., Ltd is celebrating a significant milestone in its collaboration with Neurocrine Biosciences Inc.

How is Oracle technology helping CROs enable pharma to get trials up and running?

15-Apr-2024 By Liza Laws

Michael Fronstin, global head of client partnership and commercialization at the company said the combination of Oracle’s life sciences expertise and platform technology help CROs win more business and run trials more efficiently.

AstraZeneca study forecasts 16.5% population affected by chronic kidney disease by 2032

15-Apr-2024 By Liza Laws

AstraZeneca's latest modelling analysis, IMPACT CKD, presented at the 2024 ISN World Congress of Nephrology (WCN'24) in Buenos Aires, paints a concerning picture of the future of chronic kidney disease (CKD) across eight countries.

Bristol Myers Squibb completes $14 billion acquisition of Karuna Therapeutics from PureTech

19-Mar-2024 By Liza Laws

Yesterday (March 18) PureTech Health plc announced the completion of the acquisition of its founded entity, Karuna Therapeutics, Inc., by Bristol Myers Squibb for a staggering $14 billion.

Metabolon introduces ‘groundbreaking’ bioinformatics platform

01-Mar-2024 By Progressive data analytics platform bioinformatics launched by Metabolon

Metabolon, Inc., a prominent figure in metabolomics solutions, has launched a seminal integrated bioinformatics platform, aiming to redefine metabolomics analysis in life sciences research.

uMotif teams Up with MoCA Cognition to enhance CNS research data capture

26-Feb-2024 By Liza Laws

In a significant move aimed at revolutionizing Central Nervous System (CNS) research, eCOA/ePRO platform provider uMotif has announced a strategic partnership with MoCA Cognition, the creators of a recognized test for early cognitive impairment detection.

SCOPE 2024

Revolutionizing clinical trials with generative AI: A discussion with IQVIA's Wing Lon Ng

23-Feb-2024 By Liza Laws

In the fast-evolving landscape of healthcare and pharmaceuticals, the role of technology, particularly artificial intelligence (AI), is becoming increasingly prominent.

SCOPE 2024

From Prinicpal to Univo IRB, Julie Blasingim on a mission to revolutionize research ethics

21-Feb-2024 By Liza Laws

This week Univo IRB was announced as the new company name for Principal IRB.

First patient dosed using oral PROTAC in development for neurodegenerative diseases

20-Feb-2024 By Liza Laws

A clinical-stage biotechnology company creating a new class of drugs today (Feb 20) announced that a first subject has been dosed in a phase 1 clinical trial.

Trialbee announces partnership with Massive Bio to share mission of reaching more patients than ever

05-Feb-2024 By Liza Laws

Trialbee’s Maggie Adamski says that finding patients with cancer to participate in a particular trial is like finding a needle in a haystack.

Newron's antipsychotic add-on drug produces 'never reported before' positive results

04-Jan-2024 By Liza Laws

Positive results of a study into the effects of an add-on to antipsychotics for the management of treatment-resistant schizophrenia (TRS) have been announced by Newron Pharmaceuticals.

Center focused on finding cure for glioblastoma reveals AstraZeneca drug may be a success

21-Oct-2023 By Liza Laws

A small molecule kinase inhibitor has been trialed in humans for the first time as part of a glioblastoma treatment study.

CRF study smashes diversity targets in trials with three times national average

10-Oct-2023 By Liza Laws

Complete clinical trials solution company, Hawthorne Effect, announced today (October 10) it had successfully recruited more than 1,000 patients in 48 states plus Hawaii for a study to qualify the prevalence of valvular heart disease (VHD).

DPHARM 2023

DPharm 2023 deep dive: IQVIA the important balance between the patient and technology

05-Oct-2023 By Liza Laws

At DPharm 2023, there was a huge meeting of minds to discuss the latest innovations in clinical trials. Outsourcing Pharma was delighted to have an in-depth discussion with IQVIA’s Elan Josielewski, senior principal and head of operations, patient centered...

Cannabis-based, non-cancer, chronic pain trial approved by NHS ethics committee

01-Aug-2023 By Liza Laws

The National Health Service (NHS) research ethics committee has approved a non-cancer chronic pain clinical trial being rolled out by private health clinic LVL Health.

AstraZeneca's Imfinzi has the potential to 'redefine care for patients with gastrointestinal cancers' interim analysis shows

08-Jun-2023 By Liza Laws

A new treatment approach to improve outcomes for patients with earlier stages of gastric and gastroesophageal junction cancers has had positive high-level results from a planned interim analysis of a phase 3 trial.

Clinical Trials Day 2023

Clinical trial diversity - a Q&A with Clincierge

01-Jun-2023 By Liza Laws

The US Food and Drug Administration will soon require researchers and companies seeking approval for late-stage clinical trials to submit a diversity plan for trial participants. Scott Gray, CEO of Clincierge, discusses how trial sponsors and CROs can...

Modern clinical trial needs of small and emerging biotech companies addressed by new partnership

25-May-2023 By Liza Laws

A partnership has been formed between Allucent, a biopharma services provider, has partnered with Thread, a decentralized clinical trial (DCT) and eCOA technology provider to launch Allucent Patient Direct Trials, a DCT focusing on small and mid-sized...

Breakthrough that could put an end to invasive surgery for rectal cancer patients

12-Apr-2023 By Liza Laws

A breakthrough in rectal cancer treatment has been discovered through a collaboration between a cancer intelligence company and the world’s largest and oldest cancer center. It could put an end to the invasive surgery patients may have faced.

Positive topline results in trial for patients with early breast cancer

28-Mar-2023 By Liza Laws

Patients with early breast cancer (EBC) could benefit from a targeted treatment that can block or interfere with cancer cell growth.

UK pushes ahead with biggest clinical trial overhaul in 20 years

27-Mar-2023 By Ben Hargreaves

Amid uncertainty over the future of clinical trials in the UK, the MHRA announces that it will streamline the process of running trials to make the country a more ‘attractive destination’.

iOnctura's roginolisob has potential for patients with solid and hematological tumors

21-Mar-2023 By Liza Laws

Non-clinical research has been published about roginolisob, iOnctura’s non-ATP competitive alloseteric modulator of PI3Kδ, for the potential treatment of patients with solid and hematological tumors.

LEO Pharma and ICON plc collaborate to improve outcomes for dermatology patients

14-Mar-2023 By Liza Laws

A strategic partnership between LEO Pharma and ICON plc, a clinical development company, was announced on March 10.

Frontotemporal dementia study expanded by Centogene

06-Mar-2023 By Liza Laws

Mutation in the progranulin (GRN) gene is just one of several hereditary factors that can cause frontotemporal dementia, a rare and rapidly progressive neurodegenerative disease.

Metrion leases facility, adds high-throughput capacity to support ion channel services

08-Dec-2022 By Nick Taylor

Metrion Biosciences has leased a new facility and added high-throughput screening (HTS) capacity to support its ion channel drug discovery projects.

Altasciences expands Missouri bioanalytical site to support preclinical and clinical studies

01-Nov-2022 By Nick Taylor

Altasciences is expanding its facility in Columbia, Missouri to provide bioanalytical services in support of preclinical and clinical studies conducted in the US.

Anji Pharma and Population Health partner to progress lead candidates

31-Oct-2022 By Ben Hargreaves

The biopharma company and investment firm will cooperate to progress late-stage clinical assets in diabetes and chronic idiopathic constipation.

Industry body points to ‘clear and serious threat’ to clinical research in UK

26-Oct-2022 By Ben Hargreaves

The ABPI releases a report that shows the number of clinical trials taking place in the UK fell by a large amount between the years 2017 and 2021.

TransCelerate CEO: Speeding drug development a ‘win-win’ for all concerned

28-Sep-2022

TransCelerate BioPharma continues to work towards “bringing new medicines to patients faster”. We caught up with the organization’s CEO to hear about its main achievements over the past decade and learn about what comes next.

Use of RWE, AI elevating drug development: Sidley

12-Sep-2022 By Jenni Spinner

A fleet of legal professionals offers advice and perspective on important considerations when harnessing artificial intelligence and real-world evidence.

Real-world evidence helps accelerate research: Wolters Kluwer Health

12-Sep-2022 By Jenni Spinner

Experts from the health information specialist explain how the use of RWD and RWE has helped speed up and improve the development of therapies and vaccines.

Clarify, Datavant team up to securely connect first-party and real-world data

07-Sep-2022 By Nick Taylor

The companies will work together to help clients connect information sources, giving stakeholders a better overview of the clinical patient experience.

Sanofi strikes $20m AI drug discovery deal with Atomwise

07-Sep-2022 By Nick Taylor

The pharma company’s collaboration with the drug discovery specialist involves using artificial intelligence to discover and develop up to five drug targets.

Charles River opens research facilities in California and Washington

30-Aug-2022 By Jane Byrne

Organization extends turnkey research facility network to San Diego, San Francisco, Thousand Oaks, and Seattle.

Celanese lands Gates Foundation grant for refillable contraceptive research

29-Aug-2022 By Jenni Spinner

The company has landed funding from the Bill and Melinda Gates Foundation for research and development on a prototype of a refillable contraceptive solution.

BMS expands precision oncology portfolio with Turning Point acquisition

18-Aug-2022 By Jenni Spinner

The pharmaceutical company has completed acquisition of Turning Point Therapeutics, a company specializing in precision medicine solutions for cancer patients.

Merck engages Saama Technologies to build ‘clinical data layer’

18-Aug-2022 By Jenni Spinner

The pharma firm will leverage the ClinTech leader's Life Science Analytics Cloud to bolster development capabilities and accelerate pipeline progress.

Auransa, Polaris harness AI, quantum computing to discover cancer drugs

16-Aug-2022 By Jenni Spinner

The AI and QC specialists have joined to use AI and QC in order to discover biological pathways relevant to the treatment of triple-negative breast cancer.

Merck partners with Cerevance on Alzheimer’s research initiative

11-Aug-2022 By Jenni Spinner

The pharmaceutical company has inked a strategic collaboration with the drug discovery firm, centering on uncovering novel targets in Alzheimer’s disease.

J&J, Evotec partner on ectodomain shedding drug discovery project

11-Aug-2022 By Jenni Spinner

Janssen has formed a strategic collaboration with the drug discovery specialist that involves applying TargetAlloMod platforms to protein homeostasis.

MCI OneHealth, MDClone team up to use synthetic data to accelerate research

09-Aug-2022 By Nick Taylor

The two companies are collaborating to generate subject data sets designed to help users find insights that can speed up research and improve patient care.

Medical specialty societies can benefit from regulatory progress: IQVIA

04-Aug-2022 By Jenni Spinner

An expert from the trial tech firm explains how the 21st Century Cures Act and other recent regulatory advancements can elevate clinical data registries.

Boehringer, Seqster ink 3-year health data deal to accelerate research

04-Aug-2022 By Nick Taylor

The pharmaceutical company has forged a partnership with the life-sciences tech firm in an effort to elevate data collection and speed up clinical studies.