Processing equipment

CPhI Worldwide 2019

Exothermic reactions at -60°C for continuous API manufacture

11-Nov-2019 By Vassia Barba

Driven by market demand, De Dietrich develops an API production set that enables continuous manufacturing of molecules that require exothermic chemical reactions.

Embracing the digital world for optimised drug manufacturing

30-Oct-2019 By Vassia Barba

In-PharmaTechnologist steps inside Siemen's Digital Experience Centre to learn about the digital services that aim to transform the manufacturing of pharmaceuticals.

GSK and AZ on continuous manufacturing platform ‘grand challenge’

14-Oct-2019 By Vassia Barba

A consortium between CPI and the University of Strathclyde aims to create a direct compression platform for continuous manufacturing of oral solid dosage drugs.

‘This case is about the color purple’: GSK’s suit against Sandoz refuted

07-Oct-2019 By Ben Hargreaves

England’s High Court throws out the claim that Sandoz’s inhaler product passed off the appearance of GSK’s rival through its use of the color purple in packaging.

The five potential sources of nitrosamine contamination

02-Oct-2019 By Ben Hargreaves

With nitrosamines back in the headlines due to the recent discovery of contaminants in ranitidine, the EMA releases the five potential causes of the impurities plaguing the industry.

Merz completes construction of new plant and filling line

17-Sep-2019 By Ben Hargreaves

Merz announces that it has completed the construction of a new plant for its botulinum neurotoxin product and unveils a ‘robot-controlled’ filling line.

Mallinckrodt agrees to sell CDMO business for $250m

11-Sep-2019 By Ben Hargreaves

Amid opioid lawsuits, Mallinckrodt looks to slim down its overall business by agreeing the sale of BioVectra to HIG.

Urovant ramps up spending on Codexis ingredient ahead of commercial production

13-Aug-2019 By Nick Taylor

Urovant Sciences’ preparations to file for US approval of vibegron add to Codexis’ sales in the second quarter.

Permira Funds acquires Cambrex in $2.4bn deal

08-Aug-2019 By Vassia Barba

Cambrex is acquired by an affiliate of Permira Funds for $2.4bn, and will continue investing ‘aggressively’ to support its global customer base.

Is ‘lack of control’ in supply chains the root cause of API impurities?

07-Aug-2019 By Maggie Lynch

API recalls have sparked discussion on the development of impurities during manufacturing and the ways in which risks can be mitigated, according to an industry expert.

GSK completes $95m investment for continuous manufacturing in Singapore

06-Aug-2019 By Ben Hargreaves

GSK opens two continuous manufacturing facilities and expands an existing production building to shorten timelines in the production of daprodustat.

Acquisition adds European design to ACG’s manufacturing services

06-Aug-2019 By Maggie Lynch

ACG Engineering acquires Xertecs to add European design to its existing Indian engineering and manufacturing capabilities as it globalizes.

Demand for Gardasil leads to $650m investment in Merck’s operations

30-Jul-2019 By Maggie Lynch

Merck to invest in its North Carolina facilities as it expands production capacity to meet demand for its HPV vaccine Gardasil, and grow its packaging operations

Processing seals market accelerated by Industry 4.0

10-Jul-2019 By Ben Hargreaves

The pharmaceutical processing seals market is set to grow by a CAGR of 6% through to 2023, according to a report by TechNavio.

Novel manufacturing technologies ‘fit poorly’ into regulatory models, says EMA

05-Jul-2019 By Ben Hargreaves

The EMA looks to the future by posting its five key priorities to address in the coming five years, which includes the need to recruit expertise in ‘novel manufacturing technologies’.

Piramal expands high potency API facility in Michigan

27-Jun-2019 By Vassia Barba

Piramal’s $10m expansion at its site in Michigan supports ‘dramatic growth’ and ‘brings more to the table’.

Migraine treatment ‘on track’ for NDA after site qualification

25-Jun-2019 By Maggie Lynch

Zosano completes site qualification batches for its subcutaneous investigational migraine treatment and readies itself for NDA submission by the end of year.

An ‘immutable record’: Blockchain pilot program to establish security frameworks

18-Jun-2019 By Maggie Lynch

To investigate blockchain processes and make distribution information retrieval more efficient, the FDA tapped big name companies for a supply chain security pilot program.

Boehringer opens €120m facility to meet half of global demand for Respimat

18-Jun-2019 By Ben Hargreaves

Boehringer’s plant opens in Barcelona and will produce 25m units per year of Respimat to be distributed to more than 100 countries.

Lonza’s Swiss site adds HPAPI manufacturing capacity after AZ deal

17-Jun-2019 By Maggie Lynch

Lonza expands its HPAPI production capacity at its Switzerland facility after entering an agreement with AstraZeneca, and invests in manufacturing to establish efficiency.

Cambrex completes $11m labs and logistics center expansion

11-Jun-2019 By Vassia Barba

Cambrex announces the completion of a 600-square-meter facility in Karlskoga, Sweden, alongside a 3,000-square-meter warehouse.

Iovance builds gene therapy manufacturing facility in Philadelphia

30-May-2019 By Maggie Lynch

Iovance amps up clinical and commercial immunotherapy production with a $75m (€67.3m), 136,000 square-foot build in Philadelphia’s Navy Yard.

Novo Nordisk sees ‘growing interest in sustainability’ across industry

29-May-2019 By Ben Hargreaves

Although the industry may not be among the ‘frontrunners’, Novo Nordisk is seeing the benefits when it comes to recruitment and developing mutually beneficial partnerships, says director.

How can AI change the industry? Faster diagnoses and improved treatment options

22-May-2019 By Vassia Barba

Artificial intelligence tools will allow the pharmaceutical companies to make predictions about diseases more effectively than before, says ImaginAB’s CEO.

Mylan announces quarterly loss due to Morgantown restructuring

13-May-2019 By Vassia Barba

Troubleshooting in Mylan’s Morgantown facility, after a US FDA warning, has hurt the company’s first quarter results.

NEWS IN BRIEF

Nimble leaves Roche to commercialize chemical synthesis technology

09-May-2019 By Maggie Lynch

Nimble Therapeutics spun out from parent company Roche to commercialize its chemical synthesis technology for drug discovery and development.

Second CRL given to Acacia after ‘continuing deficiencies’

07-May-2019 By Maggie Lynch

Acacia Pharma receives a second CRL from the US FDA regarding its NDA, after GMP deficiencies during API production were revealed again.

Sharp ‘future proofs’ manufacturing with facility investment

06-May-2019 By Maggie Lynch

Sharp invests $21m to meet growing demand by expanding its capacity for packaging services at its Allentown, PA campus.

Novo Nordisk on track for 100% renewable energy use by 2020

30-Apr-2019 By Ben Hargreaves

The Danish company is set to use only renewable electricity to run its global production facilities by 2020, after an investment of $70m in a 672-acre solar panel installation.

Catalent invests $14m in softgel manufacturing facility

30-Apr-2019 By Maggie Lynch

Catalent’s Germany-based facility to expand to meet demand of animal-free products after $14m investment.

Catalent installing new tableting, encapsulation equipment as part of $40m investment

29-Apr-2019 By Melissa Fassbender

Catalent is installing new equipment to increase its formulation capabilities and capacity to manufacture controlled-release tablets and capsules.

Aquestive’s oral film ALS medication approved by FDA

23-Apr-2019 By Maggie Lynch

US FDA approves Aquestive’s oral film medication for the treatment of ALS using its PharmFilm technology.

Vetter’s Chicago-based manufacturing facility expansion to meet the region’s CDMO needs

18-Apr-2019 By Maggie Lynch

Completion of early-stage development site expansion at the Illinois Science and Technology Park supplies Chicago-based drug companies with refrigeration services for complex APIs.

‘Flexibility, agility and quality assurance’: Advantages of continuous manufacturing

10-Apr-2019 By Maggie Lynch

Continuous manufacturing gives agility to the supply chain that the industry did not previously have, according to a principal scientist Janssen.

UPDATED

GSK and AZ partner with CPI for continuous manufacturing facility

08-Apr-2019 By Ben Hargreaves

UK pharma giants, GSK and AstraZeneca, collaborate with CPI to build a continuous wet granulation manufacturing facility for oral solid dosage drugs.

How to tackle a sticky issue

27-Mar-2019 By Ben Hargreaves

Sticking is one of the most common issues that is faced in the manufacture of tablets, and may become a more pressing issue once continuous manufacturing is broadly adopted, suggests I Holland’s R&D manager.

Product loss mitigation through drying technology

26-Mar-2019 By Maggie Lynch

Small molecule manufacturing can result in product loss, as the materials manufactured come into contact with internal surfaces thereby impacting drying and creating disruptions in efficency and cost-effectivness.

Applications of nanotech may provide bioavailability

26-Mar-2019 By Maggie Lynch

Nanotechnology may be able to increase bioavailability in low-solubility drugs and improve a drug’s chance of success, according to Ascendia CEO.

Digoxin API supply secured through acquisition

26-Mar-2019 By Maggie Lynch

C2 Pharma acquires digoxin API product portfolio from Noblius to secure supply of the ingredient, after disruption of the supply of the API for a number of years.

Expansion of Cambrex’s Milan site makes room for APIs

21-Mar-2019 By Maggie Lynch

Cambrex completes expansion of its R&D laboratory at its Milan site and adds a 12,000-liter reactor to its manufacturing facility during a $3m investment.

Issues of quality in pharmerging countries ‘more spoken about than real’

20-Mar-2019 By Ben Hargreaves

There is a common and often unchallenged perception that manufacturing quality standards in pharmerging countries are worrisome, but Lee Newton of Lonza argues this is not the reality.

ACG expands in Latin American with announcement of its Brazilian capsule plant

18-Mar-2019 By Maggie Lynch

ACG announces plans to grow its Latin American presence with its newest capsule production plant in Brazil, as it continues to expand its facilities in Asia-Pacific and Europe.

Chi-Med in ‘prime position’ to take advantage of Chinese growth

15-Mar-2019 By Ben Hargreaves

After operating out of China for 19 years, Chi-Med’s CEO explains how the market has grown ‘very rapidly’ in the last four years.

US budget tackles drug costs and generic competition

12-Mar-2019 By Maggie Lynch

The US Government released its fiscal year 2020 budget plan, which addressed affordable prescription drug costs through increased generic competition.

TraceLink uses network to submit experimental blockchain solution to FDA

11-Mar-2019 By Maggie Lynch

TraceLink submits interoperable blockchain network solution to the FDA for the DSCSA Pilot Project Program.

Aurobindo facility receives Form 483 over procedural issues

05-Mar-2019 By Maggie Lynch

US FDA issues Form 483 to Aurobindo’s drug product manufacturing plant after it failed to follow sterile procedures.

Sanofi manufactures radiotherapy nanoparticles

26-Feb-2019 By Maggie Lynch

Sanofi agrees to produce French start-ups’ nanoparticle drug candidate indicated for the maximization of radiotherapy at its French site.

ACG opens capsule manufacturing site in Latin America

25-Feb-2019 By Maggie Lynch

ACG expands in Brazil, with the opening of a 14,000m2 manufacturing plant through a $98m investment.

Haselmeier manufacture disposable injection device after receiving allowance

25-Feb-2019 By Maggie Lynch

Haselmeier to provide assembly, labeling, and packaging services for its drug-device combination products following recent permission given to Germany-site.

FDA secures supply chain with pilot program testing tech

12-Feb-2019 By Maggie Lynch

US FDA initiates a pilot project testing innovations in an aim to inform the development of the tracking and verification systems going into effect with the DCSA in 2023.